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In summary, compared with the Simon optimal two-stage designs, our proposed BHT-A design can terminate trials of unpromising doses early, by utilizing a continuous monitoring rule and nonlocal alternative prior distributions in the hypothesis tests.
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We agree that utilizing a continuous measure of ER maximizes the use of data and may be more biologically informative.
The laboratory experiment was performed by utilizing a 32-channel, continuous-wave DOT imager [ 31] (DYNOT, NIRx Medical Technologies).
There has been some success in design of a continuous pressurized fluid extractor by utilizing a battery of vessels in series to operate on a quasi-continuous basis, and with the use of screw conveyors to produce a gas-tight plug of material, which allows the extraction to operate at the necessary elevated pressures and temperatures.
Thus, we resort to the continuous counterpart for approximation by utilizing a rounding method that sums the probability mass from x − 0.5 to x + 0.5 for each data point.
One purpose of this paper is to show the advantages that can be gained by utilizing a parametric model, which allows use of explicitly defined, continuous hazard and survival functions for tools in analysis.
The experiments were conducted on high-purity (99.999%) aluminum bicrystals by utilizing an in situ technique for the observation and continuous recording of boundary migration.
The adoption of a national breast cancer control program in Australia was facilitated by the creation of a National Breast Cancer Center in 1995 that utilized a continuous quality improvement approach to enhancing all aspects of the breast cancer experience [ 29].
However, by utilizing an integrative approach, this problem is minimized.
Briefly, g-iDEP systems utilize a continuous microchannel patterned with sequentially changing, constrictive insulating features.
This design utilizes a continuous primary ion beam and provides direct access to tandem mass spectrometry studies.
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