17 In the early 1990s, ASOs were developed by Dominski and Kole using this paradigm: by targeting the cryptic splice sites with 2′- O-methyl RNA ASOs to block the access of the spliceosome to these sites, their group was able to restore normal β-globin splicing in cells 18 and normal hemoglobin expression, to some extent, in a thalassemia mouse model.
The significant portion of cerebral intersubject variability accounted for by endogenous testosterone using this paradigm suggests that testosterone might provide a relevant physiological measure for studying alterations in social emotional behavior, such as antisocial and anxiety disorders.
Recent works focus on extending the traditional recommendation paradigms by using this user-provided unstructured information [6 9].
In the present study, we examine this by using the paradigm of length perception by dynamic touch.
It eliminates the requirements of data distribution and load balancing by using MapReduce paradigm.
This study is intended to explore the cultural values underlying the company's management control system design by using interpretive paradigm, an ethnographic method is carry out to explore the cultural meanings.
SRTs were measured by using a paradigm in which an attention-grabbing stimulus (a red circle or an animation) attracted the infant's attention to the center of the screen.
It is becoming common to study gene × gene interactions by using a paradigm of networks that includes aggregating gene × gene interaction that exists even in the absence of main effects (McKinney and Pajewski 2012).
Both labeled and unlabeled samples were subjected to offline peptide fractionation by using a Paradigm MS4 HPLC System (Michrom, Auburn, CA) equipped with a Zorbax Extend-C18 column (4.6 × 100 mm, 3.5 μm particle size, Agilent Technologies, Santa Clara, CA) and a guard column of the same packing material.
Furthermore, by using a behavioral paradigm that allows us to manipulate memory processing at different time points, we provide experimental evidence that (BDNF-dependent) pattern separation occurs during the encoding/storage/consolidation stage of memory processing.
