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The clinical disease severity was assessed by using the severity scale defined by Vazquez M et al. which classifies severity of infection based on the number and character of the lesions, presence or absence of fever, systemic signs and also the subjective assessment of the patient [32].
Equivalent multivariate linear regression analysis was performed to search for factors independently associated with retinopathy by using the severity of retinopathy as a dependent variable, and age at registration, age at onset of diabetes, duration of diabetes, sex, BMI, and skin AF as well as AUC of HbA1c over the past 15 years were used as independent variables.
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The severity of insomnia was classified by using the Insomnia Severity Index (ISI) [ 16].
Most October case-patients had pneumonia; for these, severity of illness was assessed by using the Pneumonia Severity Index, a well-established scoring system that incorporates concurrent conditions, laboratory findings, and vital signs at clinical presentation (6 ).
Also, by using the Medsger severity scale, we could not find an association between macrovascular disease and the severity of SSc.
This shortcoming also could be compensated for by using the CIPNM severity sum score.
Patients were triaged by dedicated nurses at the triage encounter point and individual patient acuity levels were then assigned by using the emergency severity index (ESI).
Baseline and monthly fatigue levels were assessed by using the fatigue severity scale (10, 18 ), and health-related quality of life was assessed by using the 36-Item Short Form Health Survey (19 ).
Although this study controlled for severity by using the claims-based severity index for RA, there are other limitations in this analysis, which are typical of any claims-based data.
Fermentable sugars production from three kind of steam-exploded oak wood was optimized by Response Surface Methodology (RSM), using the severity factor (R0), the pretreated total solids (TS%) and the enzyme loading (EL%) as variables of a central composite design.
Severity can be minimized by using the least severe procedures and sequence of procedures, and by setting humane endpoints, and, in a sequence of experiments, by setting review points and starting with lower severity studies.
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