Sentence examples for by using the selective from inspiring English sources

The contribution of macroautophagy to the degradation of α-synuclein in OLN-A53T cells was further confirmed by using the selective inhibitor of macroautophagy, 3-methyladenine (3-MA).

Such an involvement of CB2R was further validated by using the selective CB2R agonist JWH-015 (at 1.0 µM), that produced a strong and significant inhibition of T-lymphocytes proliferation.

Total cGMP-PDE activity was assessed at 1 µM cGMP and the contribution of PDE isozymes was determined by using the selective inhibitors: 10 µM nimodipine for PDE1 (Ki = 1.4 µM [30]), 20 µM EHNA for PDE2 (IC50 = 0.8 2 µM [31]) and 0.1 µM DMPPO for PDE5 (Ki = 3 nM [32]).

The increase in cytosolic [Ca2+] could be counteracted by using the selective IP3R antagonist xestospongin B (XeB), indicating a major role for IP3Rs in mediating the TAT-IDP-induced [Ca2+] rise in SU-DHL-4.

We identified Aurora kinase B as a putative novel therapeutic target in fulvestrant and tamoxifen resistant breast cancer cells, and further explored its role in signaling and growth of fulvestrant resistant T47D cell lines by using the selective Aurora kinase B inhibitors, barasertib and hesperadin.

A successful strategy for immobilization of membrane proteins is to attach the purified protein, by using the selective affinity of a genetically introduced histidine tag (His-tag), to a nickel-chelating nitrilotriacetic acid (Ni-NTA) monolayer (SAM) self-assembled on a chemically modified gold surface.

That this is due to EGFR signalling is shown by blockade using the selective inhibitor PD153035.

Lack of specificity, the main disadvantage of the cantilevers, can be overcome by using the extremely selective biochemical reactions such as receptor ligand, antibody antigen, or enzyme substrate reactions.

By using the frequency selective network and choosing the proper sampling frequency, the folded noises can be reduced.

Thus, by using the ERβ selective ligand, the anti-inflammatory effect from the neuroprotective effect of oestrogen treatment were dissociated and it was shown that neuroprotective effects of oestrogen treatment were not necessarily dependent upon anti-inflammatory properties.

The filters and Tenax were extracted by methylene chloride and hexane, respectively, followed by GC/MS analysis using the selective ion monitoring (SIM) mode.