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The mice treated with both rapamycin and bortezomib was administered by using the same schedule as described for the single drug treatment.
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In the parallel phase, one trial conducted by Rosen et al (1999) using the same schedule as used here, DLTs of projectile vomiting, headache and nausea, were reported at 190 mg m−2.
The proportion of patients who discontinued BVD therapy in our study was similar to that reported by Rodon et al. (15 vs 11%), using the same schedule in patients older than 65yearss.
Median survival in this study was the highest in arm A (9.4 months), which is comparable to the median survival reported by Cunningham et al (1998) (9.2 months) and Rougier et al (1997) (10.8 months) using the same schedule.
The same numbers of placebo tablets were given to the control group using the same schedule.
Thirteen age-matched YG8R mice were given PBS as control, using the same schedule.
Free F ab′ 2/GAH (0.36 mg kg−1) mixed with LD was injected using the same schedule.
We therefore also evaluated the combination of MegaFasL and imatinib in GIST48 by using the same treatment schedule as GIST882.
In Part B, 160 patients were randomized 1 1 to receive 300 mg AMG 108 SC or placebo, by using the same dosing schedule.
The CHOP-14 and CHOEP-14 regimen use the same schedule of drug administration, but reduce regeneration time.
The levels achieved on D3 in this study are similar to those achieved by Mimoz and colleagues using the same dosing schedule in ICU patients with VAP [ 2].
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