We conduct different case studies by using the defined methodological framework with the aim of discovering customers temporal purchasing patterns and grouping the customers' profiles to identify sets of customers with similar temporal behavior.
In the following we show that by using the same methodological approach, but now with the allele interaction concept incorporated, we are able to systematically uncover relationships between gene regulatory mechanisms, allele interaction sign motifs and gene action.
We searched Medline and Embase from 1980 to June 2013, using the methodological filters proposed by the Cochrane Collaboration to search for randomised clinical trials (see supplementary appendix).
The main objective of this study is to identify the most appropriate technology to be adopted in the region by using the environmental load point (ELP) methodological approach.
We minimized methodological artefacts by using the same plant accessions for both phylogenetic, chemical, and bioactivity studies, and by analysing our data with consistent methods.
We rated methodological quality by using the 27 item Downs and Black scale, which was developed for assessing the design and reporting of both randomised and observational studies.
For each included study, the methodological quality was assessed by using the Quality Assessment of Studies of Diagnostic Accuracy Included in Systematic Reviews (QUADAS) criteria, which is a 14-item instrument [ 9, 10].
We assessed the methodological quality of the included studies by using the Newcastle-Ottawa scale.
Methodological quality was assessed by using the QUADAS and STARD instruments.
Methodological quality was assessed by using the quality assessment of diagnostic studies (QUADAS) instrument.
