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A linkage map was constructed by using the linkage mapping function implemented in the QTL IciMapping software (Meng et al. 2015).
This score provides an estimate of disease association by using the linkage disequilibrium score (range 0 to 1, where 1 is perfect linkage disequilibrium) as a weighting for the p-value for a given SNP.
Linkage information can be incorporated, however, by using the linkage map and taking into account the Markovian nature of the ibd process underlying the genotypes of relatives at linked loci (Epstein et al. 2000; McPeek and Sun 2000; Kyriazopoulou-Panagiotopoulou et al. 2011) using methods such as RELPAIR (Epstein et al. 2000).
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Markers were traced through the pedigree by linkage analysis using the linkage disequilibrium multi-locus iterative peeling (LDMIP) method [ 7] based on information from all genotyped marker loci and the entire pedigree (using parents from generation 5000 as base population).
Mixture of ancestry as inferred from the 93 loci data set by STRUCTURE version 2.3.3 [ 46], using the linkage model [ 18].
QTL analyses were performed using the linkage map described by Hudson et al. (2012).
Users can search the assembled markers by using the chromosome name and the linkage map name in order to retrieve a unified marker set located on a target chromosome (Fig. 3a).
Because the positions of the marker loci are known, once the position γ of the QTL is given (as an unknown parameter), we can calculate the joint distribution of the m+1 genotypes as a function of γ by using the stochastic structure of the linkage.
Rarefaction curves were constructed by using the tool aligner, complete linkage clustering, and rarefaction of the RDP pyrosequencing pipeline.
The transcribed audiotapes were analyzed by theme linkage by using the constant comparative method.
The software of CLUSTER and TREEVIEW were used to cluster and visualize the data by using the correlation metric and average linkage [ 27].
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