Sentence examples for by using specific pharmacological from inspiring English sources

In this study, we identified protein kinases that are involved in regulation of ARE activity by using specific pharmacological inhibitors of protein kinases in engineered human HaCaT keratinocytes, which stably express the ARE-driven green fluorescent protein (GFP) as a reporter.

In order to test the contribution of each pathway, we targeted each by using specific pharmacological inhibitors (as shown in Fig. 1 and Suppl. Fig. S1).

To gain further insights into the mechanism of action of this putative synergism, we also analyzed the role played by several intracellular kinases by using specific pharmacological inhibitors.

Involvement of cellular signaling pathways, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK1/2) and phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) in mushrooms-stimulated neuritogenesis were examined by using specific pharmacological inhibitors.

Furthermore, the effects of cellular signaling pathways, MEK/ERK1/2 and PI3K/Akt in the potentiation of neuritogenic activity in PC-12 cells by using specific pharmacological inhibitors were investigated.

To elucidate the mechanisms by which IL-1β upregulates L-PGDS expression, we evaluated the roles played by downstream signalling cascades using specific pharmacological inhibitors.

To gain further insights into the mechanism by which leptin, together with IL-1, promotes NO production, we evaluated the roles played by downstream signalling cascades using specific pharmacological inhibitors.

Molecular signalling of oestradiol-mediated HIF-1 α expression was studied using specific pharmacological inhibitors and small interference RNA by co-immunoprecipitation and western blotting analysis.

Confirmation of these pathways using specific pharmacological inhibitors further indicated their involvement in the regulation of CXCL10 expression.

The signalling pathways examined previously were characterized extensively using specific pharmacological inhibitors and shown to be critical for induction of cholangiocyte apoptosis after CD154 ligation.

Using specific pharmacological inhibitors, we found that profilin-dependent DNA synthesis required multiple signaling events including PI3K, Src, and Erk1/2 activity, whereas PLCγ was not required.