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These four purification methods were prepared by using specific ligands (RAC and RAC-ovalbumin) and commercial ligands (protein G and protein A), respectively.
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Several PPAR isoforms were characterized for their roles in macrophages using specific ligands.
Blocking the interaction between VLA-4 and its ligands expressed on BM stroma, by using specific antibodies or small molecule inhibitors, induces rapid mobilization of HSPCs in humans, primates, and mice [ 47, 48].
This analysis showed both immunoprecipitated IL-15 ligand and receptor by western blotting using specific antibodies (Fig. 7).
To test the specificity of LGP2 for responses to cytosolic PAMPs, Toll-like responsesresponses were also evaluated in the macrophages by using ligands specific for TLR3 and TLR4.
As such, it remains to be investigated which TLR is regulated by RP105 in these models using more specific ligands and whether the in vitro activation and cytokine production from various cells (for example, macrophages and synovial cells) are altered in the absence of RP105.
Our first set of experiments used specific TLR4 and TLR2 ligands to elicit inflammation.
Thus, doping can be controlled by using these ligands.
Tumor targeting may be accomplished by using a tumor-specific ligand, such as folic acid.
Tumor-specific cytotoxicity of drugs can be enhanced by targeting them to tumor receptors using tumor-specific ligands.
Table 3 summarizes the tissue-specific pro-apoptotic and anti-proliferative functions of PXR; in these studies, the activity of PXR was induced either by constitutive activation or pharmacologically by using ligands of PXR.
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