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Guided by mechanistic understanding of the underlying defect, it might be possible to correct this by using small molecules that weaken or strengthen dynein.
Arita-Morioka, K., Yamanaka, K., Mizunoe, Y., Ogura, T. & Sugimoto, S. Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.
Interestingly, the CASD lineage conversion has been accomplished by using small molecules and growth factors in a chemical-only paradigm.
At current study, we applied a defined neural induction medium by using small molecules for direct differentiation of hADSCs into anterior neuroectodermal cells.
In a therapeutic context, DAXX H3.3 interaction can be disrupted in PTEN-null cells using staple peptides as reported by Kim and collegues61 for the disassociation of an EZH2-EDD complex in a leukaemia model; or by using small molecules which have been efficient at antagonizing chromatin associated proteins and their interactions with other proteins62.
Recently, there have been significant achievements in cardiac reprogramming by using small molecules alone.
Similar(45)
This strategy was demonstrated by using small molecule biotin and its binding protein streptavidin (SA) as a model case.
Finally, efficient DSSCs were achieved by using small molecule TPA-type dyes FWD1, FWD2 and FWD3 as the sensitizers.
In summary, exfoliation of layered ZrP nanoplatelets has been accomplished by using small molecule intercalating agents with high polarity in ionic liquids under mild sonication.
Here, we report the exfoliation of layered zirconium phosphate nanoplatelets by using small molecule intercalating agents in ionic liquids, which opens a new platform for fabricating single-layered inorganic materials from synthetic layered compounds.
Another method to activate Sir2 is by using small molecule activators of Sir2, such as resveratrol [ 12].
More suggestions(17)
by using small doses
by using small trays
by using small form-cutters
by using bifunctional molecules
by using small tools
by using small stones
by using small arrays
by using small pulses
by using small RNAs
by using small numbers
by using small populations
by using small quantities
by using organic molecules
by using small values
by using synthetic molecules
by using small sprouts
by using small sets
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