Sentence examples for by using small ligands from inspiring English sources
An alternative approach, named kinetic inhibition, aims to prevent fibril formation by using small ligands that stabilize the parent protein.
Since each CPU works on one ligand block at a time and these blocks are continuously requested by the available CPUs during a DOVIS run, by using small block sizes (N << total number of ligands) this scheme can provide an effective mechanism for automated, dynamic load balancing.
N-6 inhibits TR3-stimulated transactivation of Gal4-DBD-RXRα-LBD by binding to the ligand binding pocket of RXRα-LBD, suggesting a strategy to regulate TR3 activity indirectly by using small molecules to target its interacting partner RXRα.
Inhibition of TGF-β signaling has focused on disruption of the ligand-receptor interaction with neutralizing antibodies or by inhibition of the receptors using small molecule inhibitors of the receptor kinase activity [29].
The targeting of G4 structures using small molecules offers the potential to intervene with biological processes.[ 3a, b, 17] We are therefore interested to see whether RTS could probe RNA G4 targeting by a stabilizing ligand, as this could validate the molecular target and provide insights into ligand selectivity.
Thus, doping can be controlled by using these ligands.
Finally, the fusion model was used for the identification of a novel generation of lead-like antiprotozoan compounds by using ligand-based virtual screening of 'available' small molecules (with synthetic feasibility) in our 'in-house' library.
By using water soluble phosphorous ligands, the catalytic complex can be kept in aqueous phase.
This is perhaps the first example of RNA binding protein regulation by a small molecule ligand, similar to the many examples of transcriptional regulators, such as the nuclear hormone receptors, that are regulated by small ligands.
Tumor targeting may be accomplished by using a tumor-specific ligand, such as folic acid.
Use of small ligand molecules has the advantage of maintaining the minimal hydrodynamic (HD) size.
