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We attempted to corroborate the construct validity of the three tests by using rat strains that were expected to differ in emotional reactivity.
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We show that Single Nucleotide Polymorphisms (SNPs) in commonly used rat strains are surprisingly well represented in wild rat isolates.
Here, we investigated four commonly used laboratory rat strains: Wistar, Sprague Dawley, Long-Evans and F344.
Among the commonly used experimental rat strains, the Wistar Kyoto (WKY) rat strain is susceptible to induction of CRGN, whereas the Lewis (LEW) rat strain is resistant.
Genotyping 36 commonly used inbred rat strains showed that 84% of these alleles are also polymorphic in a representative set of laboratory rat strains.
Another explanation is that there are rat genomic regions associated with mammary cancer risk yet to be discovered by using additional inbred strains, more extensive analysis of strains previously studied, and different methods of carcinogenesis induction.
All rat experiments used Sprague Dawley rat strain.
These results have implications for studies on F344 and other photoperiodic strains of rats, particularly because the F344 rat is widely studied throughout the world, and has been the most commonly used inbred rat strain in the United States [ 32].
In the spring we became infested with a rat population but were able to get rid of most of them by using a common rat repellent.
These aging studies were performed by the same group using the same rat strain and similar methodology.
As pointed out by Ryan et al. (2010b), CD-1 mice respond to low doses of exogenously administered estrogens, as do the rat strains used by these authors (Ryan et al., 2010b).
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