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We studied the genome-wide gene expression profile on microarrays and molecular networks by using pathway analysis tools of bioinformatics.
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As an example, we try to put these genes into a biological context via analyzing the cell cycle related genes affected by TS over-expression using pathway analysis, and the results are shown in Figure 7. It's quite clear that TS over-expression decreases p53 level, thereby affecting its downstream genes such as p21 and the rest of the cell cycle related genes.
The representative pathways were generated using pathway analysis tool, by Fisher's Exact test and the C. reinhardtii KEGG database (http://www.genome.jp/).jp/
A diverse signature was observed across these modules using pathway analysis, marked by differences in B cell and NK cell activity, as well as cellular markers of viral infection.
Gene ontology and pathway analysis were performed by using pathway miner of the Bio-resource for Array Gene System (Biorag, http://www.biorag.org/).
We next wanted to identify the biological processes influenced by the engagement of CD49f and HSP60, connexin 45 and CD151 in HUVECs treated with either anti-US28 or anti-UL122 antibodies by using a pathway analysis software (Pathway Studio).
Pathway analysis of all 492 genes (unadjusted p-value < 0.05) by using ingenuity pathway analysis (IPA) software revealed cancer as top associated "biological function".
The regulatory network can be formulated by representing it as reactions in the stoichiometric matrix and then the integrated network can be analyzed by using extreme pathway analysis.
Then they analyze the integrated network by using extreme pathway analysis [ 29].
By using KEGG pathway analysis for the SRF, MKL1, and ELK4 bound genes, I found that MKL1 and ELK4 associated genes contribute to different pathways related to SRF.
The functional significance of genes that showed differential expression between young and old tendon was determined by using ingenuity pathway analysis.
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