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By using murine models, it was demonstrated that sex hormones and dehydroepiandrosterone play important roles in sex-specific immune responsiveness following blood loss, trauma and injury.
In this study, we examined whether cold-inducible RNA-binding protein (Cirp) controls reactive oxygen species (ROS) accumulation and development of HCC by using murine models of hepatocarcinogenesis and human liver samples.
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The notion of toxic and inflammatory effects of lipid metabolites has been supported by an extensive literature using murine models of hyperlipidemia such as strains genetically deficient in either the low-density lipoprotein receptor (LDLR) or apolipoprotein E (ApoE).
The search for underlying mechanisms can be facilitated by reducing the heterogeneity of environmental and genetic factors using murine models of the human condition.
Twelve studies were performed using murine models.
Further, the recombinant human form has been used in several previous studies using murine models.
An important set of experiments in the study by Schauer and colleagues used murine models of gouty inflammation in vivo.
To investigate the fitness of quinolone-resistant S. pneumoniae (QRSP), the relative growth efficiencies of 2 isogenic QRSP double mutants were compared with that of their fluoroquinolone-susceptible parent, EF3030, by using murine nasopharyngeal colonization and pneumonia models.
The widely used murine model for neuroblastoma is TH-MYCN transgenic mouse established by Weiss et al. [3], which is currently provided by National Cancer Institute (NCI).
The most commonly used murine model of MS relies on the induction of autoimmunity by immunization of mice with specific myelin peptides and complete Freund's adjuvant.
A frequently used murine model is based on the intrarectal administration of TNBS and produced human-like CD and is characterized by Th1-mediated inflammation [ 34].
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