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So we study cell adhesion both by the methods of molecular cell biology and by using mouse models genetically modified in their cell adhesion functions.
Recently, the function of AAMs was addressed either by depleting them or by using mouse models deficient in their signature molecules like Arg1 and Fizz1.
Angiotensin II has been widely used to investigate kidney [ 5], heart [ 6], and liver [ 16] fibrosis by using mouse models.
Furthermore, by using mouse models of breast cancer, they demonstrated that CD73 overexpression in tumor cells conferred chemoresistance to doxorubicin dependent on the activation of A2A adenosine receptor.
Remarkable advances have been made in recent years towards therapeutics for cognitive impairment in individuals with Down syndrome (DS) by using mouse models.
By using mouse models, it was shown that PODXL is a WT1 target gene with high expression levels in podocytes and highly differentiated kidney epithelial cells (48).
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The antidepressant-like effect of chiisanoside from the leaves of Acanthopanax sessiliflorus was evaluated by using mice models of depression, forced swim test (FST) and tail suspension test (TST).
By using mice models of breast cancer, they found that treatment of tumor bearing mice with either anti-CD73 mAb or APCP decreased tumor angiogenesis [ 45].
In this review, we will mainly focus on those discoveries pertinent to the physiological functions of Smad7 by studies using mouse models.
These could be addressed by additional research using mouse models.
(Much of the earlier work has also been corroborated by other labs, also using mouse models).
More suggestions(15)
by using mouse genetics
by using mouse cardiomyocytes
by using instrument models
by using environment models
by analyzing mouse models
by using mouse anti-HA
by using compartment models
by using emission models
by establishing mouse models
by using regression models
by using mouse fibroblasts
by using mouse antibodies
by using foam models
by using mouse cells
by using terrain models
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