Sentence examples for by using linkage analysis from inspiring English sources

By using linkage analysis and recent genome-wide association studies (GWAS), several loci have been identified as risk factors for the development of psoriasis [4] [13].

In the past few decades, many genes which are implicated in simple, monogenic disorders have been discovered by using linkage analysis and positional cloning approaches.

For families 7 11, we elucidated the presence of locus heterogeneity by the identification of NSHI variants using linkage analysis, NGS or both.

Fewer QTL were detected using linkage analysis than using GWAS.

The QTL are then mapped using linkage analysis (LA) methods.

First, they used linkage analysis followed by candidate gene sequencing to identify a second defective gene in the mevalonate pathway that causes this disorder, mevalonate decarboxylase (MVD).

We used linkage analysis followed by sequencing to investigate whether a mutation in one of these genes is responsible for TNS in Border collies.

Efforts to localize prostate cancer susceptibility alleles by using genetic linkage analysis methods have been hindered by genetic heterogeneity, incomplete penetrance, disease phenocopies, and the lack of DNA samples from parents of individuals with late-onset prostate cancer.

The EXT phenotype was shown to be linked to the EXT2 gene by using 2-point linkage analysis.

By using microarray and linkage analysis, an association was found, both in rats and humans, between increased left ventricular mass and elevated expression of the extracellular matrix protein osteoglycin (Petretto et al., 2008).

By using nonparametric analysis, significant evidence for linkage was noted for chromosome 4 [ 83].