8 All households were georeferenced by using global positioning systems.
The fold-change values of identified 372 proteins (Additional file 1) by using the Reporter Ions Quantifier with the TMT 6-plex method were normalized using global median.
Using global expression data, we first selected K4-dependent and K4-independent genes that were repressed by at least two-fold in all five colon cancer cell lines relative to five epithelial colon crypt samples.
Furthermore, the fold of this protein was not represented in the training set and thus this protein could not have been correctly predicted using global structural similarity.
Pathways were identified using global test [38].
This option should be used only for short input sequences as the base pairing probabilities are calculated here using the global folding method RNAfold.
Stringent signature probes were chosen by using fold-change > 1.5 and global FDR < 0.05.
The value of n was determined by using 10-fold cross validation of the reference set.
For each classification model we evaluated several feature selection approaches by using 10-fold-cross-validation.
For all data sets, the classification performance is assessed by using 10-fold cross validation (CV).
