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Normative data for HRQOL by using generic instruments exist for the questionnaires EuroQOL (EQ-5D) [ 2, 3] and The Medical Outcome Study 36-item SF36t-Form Health Survey (SF36) [ 4] which are proven to be useful and validated tools [ 5- 8].
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HRQOL can be assessed using generic instruments, which allow comparison between patients and general populations.
Only a small number of studies used generic instruments like the EQ-5D.
Medical outcome studies use generic instruments to compare results between different settings with different case mixes.
HRQoL was assessed using the 36 Short Form (SF-36) health survey questionnaire [11], a widely used generic instrument developed by the Rand Corporation for the Medical Outcomes Study, which has been tested, validated and used in many chronic diseases including headache [12].
The SF-36 is a widely used generic instrument for assessment of health status.
Currently, the EQ-5D is the most commonly used generic instrument for CUAs [ 14].
The SF-36 is a widely used generic instrument to assess health-related quality of life.
This can only be achieved by using generic (non disease-specific) health-related quality of life (HRQoL) instruments that produce a single index number (utility).
Various studies have attempted to explain ICU stay-related variables by using identical generic instruments to compare critically ill patients' health-related quality of life with that of comparison groups from the general population [ 4, 9, 41, 42].
Suitable methodologies for cost-utility analysis (CUA) would mean using generic descriptive instruments or a generic health scale [ 8].
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