Patterns were identified by latent class analysis, using concomitant variables to predict class membership.
We will also estimate 'off-label' use of cancer medicines by using information about concomitant use of specific cancer medicines.
A study in South African children aged seven months to 3.9 years showed that it is possible to attenuate the tendency of lopinavir levels to decline in the presence of the TB drug, rifampicin, by using a higher dose of concomitant ritonavir (lopinavir/ritonavir ratio of 1 1 instead of the usual 4 1) [ 83].
We enrolled more ordinary patients than the specially selected individuals usually included in clinical trials by using wide inclusion criteria, and allowing concomitant illnesses and medications.
This highlights the clinical relevance of reducing ICH by using apixaban rather than warfarin and avoiding concomitant aspirin, especially in patients of older age.
Moderate heterogeneity however (I 2 = 48%, p = 0.15 for interaction) was observed among subgroups divided by use of concomitant lipid-lowering therapy, suggesting this may account for some of the variability in the effect observed.
Low to moderate heterogeneity (I 2 = 33%, p = 0.23 for interaction effect) was observed among subgroups divided by use of concomitant lipid-lowering therapy, which was largely due to the difference in effect observed in the subgroup of two trials providing statin therapy as part of the intervention arm.
The incidence of hypoglycemia was analyzed using logistic regression and categorized by use of concomitant SU.
Additionally, characteristics including age, disease duration and disease activity (measured by HAQ-DI, DAS28[ESR] and DAS28[CRP]) were similar when patients were stratified by prior anti-TNF use, concomitant MTX use at baseline and disease duration.
In the 12-week DB period, patients with active RA and an inadequate response to ≥1 disease-modifying antirheumatic drug (DMARD) were randomized 4 1 to CZP (400 mg at weeks 0, 2 and 4 then 200 mg Q2W) or placebo (Q2W), stratified by prior anti-TNF use, concomitant use of MTX and disease duration (<2 years vs. ≥2 years).
