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Firstly, the hypothesis can be tested by using computational approaches to predict the structural properties of candidate GCs and testing should include automated substrate (GTP) docking protocols.
The present study aims at indentifying potent inhibitors of mPTPB by using computational approaches of ligand based molecular modeling and docking studies.
By using computational approaches (TargetScan, miRanda, microT and miRDB), we then predicted miRNAs that were suggested to target the differentially expressed mRNAs.
The existence of orthologous conserved miRNAs in a plant species can be easily confirmed by using computational approaches, due to high conservation of many mature miRNAs across a wide range of plant species [ 45, 46], or by traditional Sanger sequencing.
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Herein we report the ability of naturally occurring drug candidate WA and its mode of action for binding to mammalian 20S proteasomes as macromolecular receptors using computational approaches by analyzing the interactions between WA and the proteasomes.
His laboratory has taken a systems-level approach to understanding cellular behavior by making large-scale global observations and using computational approaches to infer the key underlying components and their organization into regulatory and genetic networks.
This is not unexpected, given that most evolutionarily conserved microRNAs are likely to have already been discovered using computational approaches followed up by directed validation experiments.
ChIP-Seq of RNA Pol II was used to identify the bidirectional promoter by detecting bi-peak shapes using computational approach [ 10].
We therefore used computational approaches to search for GFP-like proteins encoded by the Nematostella genome (NvFPs).
To analyze methylome segmentation within RPE genomic DNA, we used computational approaches.
The molecular mechanism underlying EGCG's high-potency inhibition of human COMT has been recently investigated by using computational molecular modeling approaches [27].
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