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It was recently demonstrated by using animal models, that neurons in primary auditory cortex of anesthetized ferrets exhibit a pronounced preference to stimuli that exhibit 1/f statistics.
Further researches are anticipated by using animal models with spontaneous hemorrhagic AVM lesions.
The cerebellum has been studied mainly by using animal models (e.g., [ 20]).
It has been possible to trace the pathways linking these regions by using animal models [ 4– 6].
MMP2 as a gene-therapy target has already been studied in vivo by using animal models as a strategy to treat tumors.
The association between genetic variation of OPRM1 and the response to alcohol is supported by results obtained by using animal models mimicking the A118G (Asn40Asp) variation.
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The fucose-α(1 2 -glycans have been implicated, by others using animal models, in the molecular mechanisms that underlie neuronal development, learning and memory.
There is a wide intrafamilial clinical range of features and classical penetrance is estimated to be at least 62%.Our data suggest that SIX3 mutations result in relatively severe HPE and that there is a genotype-phenotype correlation, as shown by functional studies using animal models.
Beneficial effects of HDAC inhibitors have been demonstrated in vivo by several groups using animal models of arthritis [ 29, 32- 35].
It is interesting to note that the estrogenic effects of tamoxifen on the vaginal epithelium have been observed by other investigators using animal models [ 39- 41].
This hypothesis should be further examined by in vivo works using animal models in the future.
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