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This inspired us to investigate the mutagenicity of comfrey in rat liver, a target tissue for its carcinogenesis, by using a transgenic rat mutational model (Dycaico et al, 1994).
Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells.
A recent study by Willimsky et.al. [27], has addressed the question of immunogenicity of pre-malignant lesions, by using a transgenic mouse model for sporadic cancer.
Our results extend previous findings by using a transgenic mouse lacking the NR1 receptor subunit in DA neurons (NR1DATCre), and by confirming the absence of NMDARs in virtually all VTA DA neurons.
In this study, by using a transgenic rat expressing ChR2 specifically in the RGCs under the regulation of a Thy-1.2 promoter, we tested the possibility that direct photoactivation of RGCs could restore effective vision.
In fact, by using a transgenic mouse in which GCL-C down-regulation is induced in catecholaminergic neurons, including those of the SN, it has demonstrated that reduction in GSH levels in adult dopaminergic midbrain neurons results in nigrostriatal degeneration [44].
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By contrast, using a transgenic murine model in which expression of NF-κB in macrophages could be induced or suppressed, Connelly et al.148 demonstrated that activation of NF-κB instills macrophages with an antitumour phenotype and leads to a marked reduction of lung metastasis in a mammary tumour model.
By using a pipette, transgenic worms are then transferred to our substrates for lensfree on-chip imaging.
To test the role of early AspM-expressing forerunners, we performed their selective killing by using a novel transgenic mouse line: Nestin-GFPflox-TK mice.
At the last, by using a unique transgenic mouse model, we have documented that the post-training dephospho-eEF-2 is a molecular underpinning for protein synthesis pertinent to memory consolidation.
Active Wnt- β-catenin signaling can be localized by using a reporter transgenic mouse Topgal lacZ.
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