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Intercalate orientation is determined by using a structure model containing an energy minimized anion.
The actual molecule display, where the molecule is rendered on a HTML5 canvas using a JavaScript library, is done by using a structure drawing package from Actelion [21].
Two type ZSM-5 catalysts (Si/Al ratio of ∼30) with different mesoporosity were synthesized by using a structure directing agent of tetra-n-butylphosphonium hydroxide.
In FlowVisor, the physical network's addressing space is sliced by using a structure called flowspace [2], that indicates which values of each header fields belong to a given network.
Ding et al. [32] designed a heart-valve-like check valve by using a structure simulating the working principle of human's heart valve to increase the deformation of the valve and reduce its stress.
Our model structure is more close to the experimental results by using a nano-sphere lithography technique as revealed by the AFM observations, which is different from the previous work by using a structure of poly-Si film textured by the hemispherical nanopit array [17].
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We recently discovered a potent and selective B-Raf inhibitor, UI-152, by using a structure-based drug design strategy.
To verify this notion, the PxxP sequence was adopted as the start to derive an array of efficient SH binders by using a structure-based rational design strategy, which were then substantiated with fluorescence spectroscopy analysis and guanine nucleotide exchange test.
It should be possible to gain additional affinity by accessing an additional local binding interaction or filling a local hydrophobic pocket by using a structure-based design approach.
Sequence alignment of all proteins was made using the MALIGN [ 44] multiple alignment tool of BODIL [ 45, 46] by using a structure-based sequence comparison matrix [ 47] with a gap penalty of 40.
20 In conclusion, by using a structure-based design approach, the simple BRD binding fragment 1 has been developed into LP99, a potent and selective inhibitor of the closely related BRDs of BRD7 and BRD9.
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