To remedy this, we used the CGZAS method and improved the estimation by using a region-weighted chi-square minimisation method proposed by Mighell (Mighell, 1999).
The second step, BML segmentation, automatically identified the boundaries of the BMLs within the bone region found in the first step by using a region-based curve evolution algorithm [ 20], which was considered an optimal algorithm because BMLs often have ill-defined boundaries.
Instead of utilizing image gradient information, region-based models typically aim to identify each region of interest by using a certain region descriptor, such as intensity, color, texture, to guide the motion of the contour [17].
Lesions with pathologically increased FDG uptake obtained in the visual response assessment were determined by SUVmax using a "region of interest" (ROI) feature of a dedicated software tool (rover® v2.0.31, ABX GmbH, Radeberg, Germany).
SUVmax for both the tumor region and the normal liver was determined by using a manual region of interest (ROI) in transaxial attenuation-corrected PET slices.
For BLI analysis of primary mammary tumors, photon flux was calculated for each mouse by using a circular region of interest encompassing the primary tumor in supine position.
Photon flux was calculated for each mouse by using a circular region of interest for each lung.
The norm of reference can be one defined by professional organizations, by government policy, or simply by using a certain region as a comparator.
Photon flux was calculated for each mouse by using a rectangular region of interest encompassing the head of the mouse in a prone position.
