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By using a rationale-based strategy and a reverse target-identification approach (identifying the target(s) of a compound after unveiling its cellular phenotype or biological activity), we excavated a likely mechanism that attributes to the activation of p53 by this compound, that is inhibition of SIRT1 activity (Fig 8).
SK Telecom defended the purchase using a rationale that left some corporate critics even more perplexed.
Here, we extend the optogenetic toolset by developing a neuromodulatory approach using a rationale-based design to generate a Gi-coupled, optically sensitive, mu-opioid-like receptor, which we term opto-MOR.
Unlike parametric alternatives for time series generation, non-parametric approaches generate new values by conditionally resampling past observations using a probability rationale.
Using a similar rationale, we counted gains and losses of FSFs in individual proteomic lineages by traveling from the root to terminal leaves of the proteome tree.
The rationale for using a conservative estimation of NTHi pneumonia incidence was informed by the considerable variation amongst estimates reported in the literature [ 30- 34].
Another trend showed that students who began the course using a nodal emphasis rationale when interpreting trees shifted their rationale to focus on implied apomorphies and common ancestry by the end of the course.
The proposed rationale for using a combination of two or more different antimicrobials is several fold.
Clinton's rationale for using a private email account has changed numerous times over the past year.
Her rationale for using a private email account has changed numerous times over the past year.
The rationales for using a multilevel modeling were the following.
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