Sentence examples for by using a dominant from inspiring English sources

We therefore sought to validate the results of these pharmacological studies by using a dominant negative mutant of HDAC3 (Ser-424→Ala) which is specifically defective in its deacetylase activity [42].

By using a dominant negative p73 mutant we demonstrated that genotoxin-induced apoptosis relies on p73 activation and importantly, that p73 activation is required for Noxa expression in our cells.

Recently, a study, which aimed to analyze the direct effects of CDK9 inhibition in global gene expression by using a dominant negative form of CDK9 (DN-CDK9), showed that DN-CDK9 targets fewer genes than flavopiridol, suggesting that flavopiridol has additional effects.

Retarding the Wnt signalling pathway by using a dominant-negative LRP has been depicted to significantly reduce arterial SMC proliferation [ 23].

Then we assessed whether proliferation of T/NK cells in CAEBV requires LMP1 by inhibiting endogenous LMP1, using a dominant negative (DN) form of the protein.

Here, we examined the effect of LMP1 on EBV-negative cells using the cells conditionally expressing LMP1, and on CAEBV-derived EBV-positive cells by inhibiting the function of LMP1 using a dominant negative form of LMP1.

The contribution of PKD in dendrite retraction was validated further by genetic inhibition using a dominant-negative form of PKD1 (Fig. 7D).

By using a shifted version of the dominant vector, the re-encoding error introduced in the dominant region can be avoided.

Mislocalisation of the dystroglycan-Dbl-ezrin complex to the cytoplasm by using a cytoplasmic dystroglycan construct had a dominant-negative effect on filopodia formation [ 50].

One of the many solutions for this problem is to detect speech-dominant regions by using a voice activity detector (VAD).

By using an adenoviral vector expressing N17Rac1 dominant-negative mutant [ 32], we further studied the effect of Rac1 on IR-induced G2/M checkpoint response in MCF-7 cells.