Blinding, for example by using a blinded assessor, should be applied wherever possible.
Multidimensional LC-MS/MS analyses of trypsin-digested lens membrane fractions analyzed by TagRecon using a blind modification search revealed a 160 amu addition to Ser residues on lens proteins such as AQP0, MP20, and several crystallins.
At New Jersey Seeds, we avoid these problems by using a race-blind approach combined with a household income cap in selecting our students.
Under the assumption that 5-HT transmission may be part of the biological mechanisms mediating behavioral response to MPH, we have examined the association of the polymorphic 5-HTTLPR with behavioral response to MPH by using a double-blind, placebo-controlled crossover study to test this association.
We measured the effectiveness of blinding of participants by using a published blinding index in which values >0.5 indicate successful blinding.
Therefore, the purpose of this study was to examine the effect of KRG on pathological cold and heat patterns and cardiovascular autonomic function (CAF) by using a randomized, double-blind, placebo-controlled design.
While the current study extends previous research by using a randomized controlled design and blind assessments, there are a number of limitations that need to be taken into account.
This study complies with the CONSORT guidelines [ 63] by using: a) standardised assessment measures; b) blind assessments; c) standardised assessor training and inter-rater reliability checks; d) manualised, replicable procedures for all conditions; e) random allocation, and f) treatment fidelity checks.
The study by Lavigne et al. lacked randomization, but was strengthened by larger numbers, single (investigator) blinding, and by using a more reproducible method to measure ROM.
In parallel, histologic scoring of the degree of inflammation was performed, by using a 4-point scale, by double-blind semiquantitative analysis (DM and SR) of the lining thickness, infiltration level, and vascularity in serial hematoxylin eosin staining.
