Trend analyses and comparability tests for age-standardized or age-specific death rates plotted over time by year were conducted using Joinpoint software, developed by the National Cancer Institute.
A secondary analysis of the temporal trends was also carried out using Joinpoint software (version 3.4.3), which measures changing trends over time by selecting the best-fitting points (called joinpoints) at which the slope of the increase or decrease in rates changes significantly [ 33].
We used logistic regression, accounting for the complex sampling design, to obtain predicted prevalences and standard errors; we then tested the null hypothesis of no change points of these prevalences by glucose categories using joinpoint regression software developed by the Surveillance, Epidemiology, and End Results program of the National Cancer Institute (version 3.3; Rockville, MD).
Incidence trends in ASRs of PLC were analyzed using Joinpoint regression (Joinpoint regression software, Version 3.5.3-May 2012, available through the Surveillance Research Program of the US National Cancer Institute).
Joinpoint regression analyses were performed using Joinpoint version 3.2 software obtained from the US National Cancer Institute [ 23].
We analysed temporal trends in mortality among women of all ages using joinpoint regression, version 3.4.2 of the software from the surveillance research programme of the US National Cancer Institute.
Temporal trends from 1970 through 2006 for each cancer by sex were described using joinpoint regression analysis (permutation test) [15], which involves fitting a series of joined straight lines (a maximum of four joinpoints) on a log scale to the trends in the annual age-standardized rates [15].
We used Joinpoint Regression software (version 3.5; Statistical Methodology and Applications Branch and Data Modeling Branch, Surveillance Research Program, National Cancer Institute) to analyze trends in NLEA rates.
The crude suicide rate per 100,000 population and the trends were described using joinpoint regression analysis by determining the turning points for the 6 year period (2010 2015) using freely available software Joinpoint Regression Program, Version 4.5.0.1 (Surveillance Research program, National cancer Institute, USA) (Program, 2017).
