Sentence examples for by upregulating their expression from inspiring English sources
STAT6 is activated during this transition and promotes IL-4/IL-13-mediated differentiation of wound healing/profibrotic (M2) macrophages by upregulating their expression of arginase (Arg1) and multiple other wound healing/profibrotic phenotype genes [101].
Together, these findings suggest that one mechanism by which PPR signaling in T cells augments the osteoclastogenic activity of SCs is by upregulating their expression of CD40.
In addition, T cell produced TNF augments the sensitivity of SCs to cPTH by upregulating their expression of CD40 (Fig. 7).
Yang et al. [ 28] found that TAMs mediate tumorigenesis through regulation of breast CSCs and promote CSC-like phenotypes in murine breast cancer cells by upregulating their expression of Sox-2.
Our previous studies have demonstrated that MSCs become immunosuppressive in the presence of interferon- γ (IFN- γ), tumor necrosis factor- α (TNF- α), interleukin-1 α (IL-1 α), or interleukin-1 β (IL-1 β) by upregulating their expression of iNOS (in mouse cells) or IDO (in human cells).
Recent work by Freed-Pastor et al. showed that mutant p53 is recruited to genes that encode MVA pathway enzymes by SREBPs proteins to upregulate their expression in human breast cancer cells, contributing to the maintenance of the malignant phenotype.
Significant finding in CHB patients showed that circulating HBV-specific CD8+ T cells were mainly PD-1 positive; in line with those observations in other different viral infections, the exhausted T cells affected by high viral loads would upregulate their expression of PD-1.
Activated Th1 cells produce IFN-γ, which initiates a positive feedback loop by priming and activating more macrophages and by upregulating their MHC class II expression.
Furthermore, we analysed the radiosensitivity of OSCC cells by upregulating ICAM2 gene expression using expression vector encoding ICAM2 cDNA.
To circumvent telomere shortening, immortal cells, like tumour cells or stem cells, express telomerase activity by upregulating the expression of the catalytic subunit of the enzyme, hTERT.
These findings indicate that T cell expressed PPR mediates the osteoclastogenic response of SCs to cPTH by upregulating CD40 expression, thereby promoting CD40L/CD40 signaling.
