Sentence examples for by two proteolytic steps from inspiring English sources
Interactions between Notch receptors and Delta or Jagged ligands result in a conformational change, followed by two proteolytic steps.
Canonical Notch signalling is activated by ligand-receptor interactions releasing the receptor intracellular domain (NICD) by two proteolytic steps, including an essential cleavage by γ-secretase.
It is a zinc metalloprotease catalyzing two proteolytic steps in the maturation of yeast mating pheromone a-factor.
Activation of PacC requires two proteolytic steps, converting the full length PacC72 to the truncated forms PacC53 and PacC27, respectively, with the latter required for the transcriptional response to alkaline pH (Diez et al., 2002).
The farnesylated LaminA protein then undergoes two proteolytic cleavage steps, by the endoprotease ZMPSTE24, culminating in the removal of the farnesyl group and the 18 C-terminal amino acids.
VEGFR2 proteolysis is tightly regulated; at least two distinct proteolytic steps have been postulated for processing within the endosome-lysosome system.
Three proteolytic cleavage steps are necessary to fully process the α-factor pre pro leader sequence, and especially the efficiency of the last step can be influenced by the amino acids surrounding the cleavage site (Goda et al. 2000; Almeida et al. 2001).
However, in the liver, GABA-T is further cleaved to a smaller isoform by a second proteolytic step catalyzed by a mitochondrial processing peptidase [ 6].
Currently, blocking Notch1 signalling by suppressing the proteolytic step, which is mediated by γ-secretase, leads to the generation of ICN1 becoming plausible (Shih and Wang, 2007).
This 664-amino-acid protein is post-translationally processed into lamin A by two transfer reactions and two proteolytic cleavages.
