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We confirmed this by two observations: a) PBDE actions are completely antagonized by cotreatment of neurospheres with T3 and b) simultaneous administration of PBDE and the THR antagonist NH-3 did not cause an additive effect.
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This view has been challenged by two observations suggesting an apparent interaction: impairment of the UPS induces autophagy in vitro, and conditional knockout of autophagy in the mouse brain leads to neurodegeneration with ubiquitin-positive pathology.
This is evidenced by two observations: (1) P3HT exhibits a good contact with PCBM in molecular level and (2) the P3HT-PCBM system forms a well-organized molecular network in each of the electron donor and accepter phases.
That these enzymes may have an important role in seizure-induced ROS generation is suggested by two observations: (1) NMDA receptors have a pivotal role in seizure-induced neuronal damage and (2) direct pharmacologic activation of NMDA receptors can activate NADPH oxidase, increasing free radical production and consequently neuronal death.
By the time the patients have developed RA, they have reached a steady state as indicated by two observations.
Our work is motivated by two observations.
The possibility that epoxidation might be involved in the activation of retinoic acid and related retinoids was suggested by two observations.
Our analysis of employment rates is motivated by two observations.
Resource flexibility was the distinct value as considered by two observations.
The second hypothesis is supported by two observations.
An effect of insulin/insulin growth factor signalling (IIS) on the timing of metamorphosis was suggested by two observations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com