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Apoptosis is primarily induced by two major pathways namely the 'extrinsic' or the death receptor-mediated or by the 'intrinsic' or the mitochondria-mediated pathways.
The main DNA damage caused by IR is double strand break (DSB), which can be repaired by two major pathways: homologous recombination (HR) and non-homologous end joining (NHEJ).
DSBs are repaired by two major pathways: nonhomologous end-joining (NHEJ) and HR [ 4].
Apoptosis is initiated by two major pathways, namely the extrinsic (receptor-mediated) and the intrinsic (mitochondria-mediated) pathways [ 12].
TCE undergoes metabolism by two major pathways, cytochrome P450 (P450 -dependent oxidation and conjugation with glutathione (GSH).
DSBs can be repaired by two major pathways according to the cell cycle phase at the time of exposure.
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Complement cascade is initiated by three major pathways: classic, alternative, and lectin pathways.
Signaling downstream of Ras is mediated by three major pathways, Raf/ERK, phosphatidylinositol 3 kinase (PI3K), and Ral guanine nucleotide exchange factor (RalGEF).
We found that at least five of the metabolites regulated in daf-2 worms, malate, acetate, succinate, glucose and trehalose, were linked by three major pathways: the glyoxylate shunt, gluconeogenesis, and starch metabolism.
Thalamic output can be suppressed by one of two major pathways.
In a general model of the global carbon cycle, the input of carbon to the oceans is balanced by its output via two major pathways, normal marine carbonate precipitation and organic carbon burial (Shackleton and Hall 1984).
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