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Analysis was conducted by two experienced data analysts, a principal investigator on the study who co-ran the focus groups (SC) and an independent analyst who was not present at the focus groups (CS, lead analyst) who had access only to the raw transcripts.
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The echocardiograms were analysed by two experienced investigators blinded on clinical data.
Images were stored on videotape for posterior offline analysis by two experienced cardiologists, blinded to clinical data.
All data were collected on predesigned data extraction sheets by two experienced reviewers.
Counting was performed by two experienced investigators without blinded to clinical data.
All measurements were performed offline, using EchoPAC™ Clinical Workstation Software GE Healthcaree), by two experienced echocardiographers, blinded to all clinical data.
All studies were digitally recorded and stored for off-line analysis by two experienced examiners blinded to patient clinical data.
Then, for quantitative scoring, radiographs were sent to the coordinating center for calculation of the total, joint erosion, and narrowing Sharp/van der Heijde score (SHS) at inclusion and 1 year by two experienced readers with blinding to patient data.
All contrast-enhanced ultrasound data were analyzed by two experienced radiologists who were blinded to all clinical and pathological information.
The data were analysed by two experienced neuroradiologists (P.S., M.H .. Raters did not receive any information about the affected hemisphere.
The PET data were evaluated in consensus by two experienced nuclear medicine specialists blinded to the results of CIM and clinical data.
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