The proteasome (or 26S proteasome) is a large multi-subunit protein complex, which is made up of two distinct subcomplexes, the 20S catalytic core and the 19S regulatory cap [14].
We speculate that this could potentially release two distinct subcomplexes, each able to reach distinct cellular destinations or interact with different partners.
The coatomer is a heptameric protein complex with two distinct subcomplexes: an inner cargo-binding heterotetrameric F-subcomplex consisting of β-, γ-, δ- and ζ-COP, and an outer cage-forming heterotrimeric B-subcomplex consisting of α-, β'- and ε-COP.
Broadly speaking we've had three eras of the web defined by three distinct behaviors.
SLITs are characterized by four distinct domains.
A general structural and functional organization is emerging in which insertion and deletion editing appears physically and functionally separated in two distinct heterotrimeric subcomplexes [18], [46].
We deleted Rsc1 and Rsc2, which are present in two distinct RSC subcomplexes [44], and show a very similar genome-wide occupancy profile [45].
All three editosomes have an identical "core" of 12 proteins that is composed of the two distinct heterotrimeric subcomplexes, four related OB-fold proteins (KREPA3, 4, 5, and 6), and two related proteins with degenerate RNase III motifs (KREPB4 and 5).
Thank you for sending your work entitled "Single molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae" for consideration at eLife.
Based on biochemical analyses, this complex can be dissociated into two functionally distinct subcomplexes, the 20S core particle (CP) which is the proteolytic component, and the 19S regulatory particle (RP), that is responsible for recognizing, unfolding, and translocating polyubiquitinated substrates into the 20S CP, where they are degraded.
