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This theory is supported by two additional studies in cancer cells, as well as our negative findings in control human tissues.
Similar results were reported by the Spanish Collaborative Study of Congenital Malformations [ 57] and by two additional studies [ 59, 61], but a reporting bias might exist because several large studies found no statistically increased rate of oral clefts [ 60, 63].
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These relatively recent prospective randomized trials were all carried out using contemporary study design concepts and methods.46 Moreover, the increasing interest in this topic is highlighted by two additional study reports meeting PMR criteria47,48 that appeared during preparation of this manuscript.
DCI was diagnosed by the treating study neurologist and confirmed in a retrospective review of each patient's clinical course by two additional study physicians.
27 Two additional studies by Glehen et al. and Shen et al. reported 5-year survival of 22%and35%5%, respectively, using MMC doses of 40 60 mg.
Two additional studies by LeBlanc et al. [ 9, 10] found that paramedics exposed to high levels of acute stress during simulation scenarios were more likely to commit errors in communication and medication dosing.
Qualitative findings from these studies and two additional studies by UNICEF suggest that the design of the beads is crucial: beads should move comfortably, and a separate bead string, with colour coding, is required for the age groups with different cut-off thresholds eliminating more complicated calculations.
In these studies, two additional studies were identified by manually searching the references in the manuscripts.
The more formal meta-analysis by Johnson et al. (2014) included two additional studies, each with < 50 subjects (Fromme et al. 2010; Kim S et al. 2011).
Among the end references of the remaining 83 studies, two additional studies were identified by the international panel of primary care experts that met the study criteria.
Similarly, two additional studies carried out by Singh et al. [ 43] and Kaushal and Kansal [ 44] demonstrated antioxidative efficacy of low-fat probiotic dahi prepared with regular dahi cultures plus L. acidophilus and L. casei as well as B. bifidum by significantly reducing the levels of TBARS in colon carcinogenesis in rats/mice in comparison to DMH control rats [ 43].
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