Because essentially all traditional NSAIDs also trigger the hypersensitivity reaction, treatment of pain and inflammation has been challenging.
Both assays rely on the production of cytokines by antigen specific T cells but the TST is a delayed hypersensitivity response that involves injection of antigen into the dermis triggering the infiltration of specific T lymphocytes into the region in a positive response.
The basophil activation test aims to reproduce in vitro the triggering of this hypersensitivity by incubating the cell with the putative allergen and to evaluate the result of this activation directly at the cellular level; thus the test provides its own pieces of information.
Pathogenicity of D. mutila under high light is proposed to result from light-induced production of H2O2 by the fungus, triggering hypersensitivity, cell death, and tissue necrosis in the palm.
The disease is an autoimmune disorder that is triggered by hypersensitivity to ingested gliadins from wheat and other cereals [18].
Sensitive skin may be triggered by hypersensitivity to a range of stimuli which may be physical, chemical, psychological, or hormonal.
Extrinsic asthma is an IgE mediated hypersensitivity reaction where the bridging of IgE triggers the release of mast cell mediators.
The term 'anaphylaxis' has been used for all types of acute life-threatening illness triggered by abnormal sensitivity (hypersensitivity) to a trigger agent, and for apparently spontaneous attacks with similar features (idiopathic anaphylaxis).
In addition, some of these drugs also provoke hypersensitivity reactions triggered by the presence of non-ionic surfactant, Cremophor EL, in the formulation.
In preclinical studies, long-term oestrogen deprivation triggered hypersensitivity to oestrogens, which is accompanied by a five- to 10-fold increase in ER expression [ 5, 6].
