Importantly, this idea is supported by the seminal research [20] demonstrating that the cellular cytoskeleton responds to gravity by triggering different cell type dependent mechanisms.
Imatinib and Fenretinide work by triggering different AM pathways of molecular signalling (by blocking the ATP binding site of BCR-ABL or by highly increasing the production of ROS, respectively).
The idea is also supported by the seminal research [20] suggesting that cellular cytoskeleton responds to gravity by triggering different cellular mechanisms.
Thus, hyperosmotic stress kills cells by triggering different molecular pathways, which converge at mitochondria where pro- and anti-apoptotic members of the Bcl-2 family exert their control.
Resveratrol provides cardioprotection by triggering different endogenous signaling pathways including oxidative stress/antioxidant defense system, glucose/insulin metabolism, iNOS/nitrotyrosine, and preconditioning, which are associated with energy metabolism [ 34- 36].
However the division happens, eventually the subpopulations evolve genetic differences (perhaps triggered by the different selective pressures in their separate environments) and become discrete species, unable to mate with one another and reunite their genes.
In the case of MDA-MB-361, the very slow growth rate of the cells in 3D may have contributed to these findings, although the difference between responses in PEG gel and Matrigel implies an actual effect triggered by the different environments.
Microstructural changes triggered by the different heat treatments also shift the damage mechanisms from internal crack initiation to initiation at the surface.
These findings strongly suggest that there is some unsystematic variance in the participants' performance triggered by the different aspects of task design.
Figure 5b shows a principal component analysis (PCA) of the global mRNA transcriptome changes triggered by the different treatments.
