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The high affinity LTD4 receptor CysLT1R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells.
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ADAM is activated by IR leading to an increased triggering cell proliferation cascade in irradiated melanoma cells [ 9], specifying ADAM's blockage as an attractive target to radiosensitize this tumor type.
Genetic deletion of HIF-1α in T cells resulted in increased TCR triggered cell proliferation as shown by significantly higher percentages of cells which had undergone three or four cell divisions upon anti-CD3 mediated activation (Fig. 3A).
These autocrines powerfully trigger cell proliferation and tumor angiogenesis [ 34– 34].
The platelet releasate comprises of a multitude of inflammatory and vasoactive substances, which can attract atherogenic leucocytes from the circulation, activate endothelial cells and stimulate vessel growth and repair by triggering vascular cell proliferation, migration and inflammation [ 37].
In mammals, ROS are also crucial regulators of prenatal and embryonic development (Dennery 2004) and immune system by triggering T cells proliferation through NF-κB activation (Tatla et al. 1999).
An intriguing finding related to the autocrine function of VEGF signaling in tumors was that VEGF secreted by tumor cells triggers tumor cell proliferation by binding VEGFR1 expressed on the same cell.
When DNA damage persists unrepaired, DDR can trigger cell death by apoptosis or halt cell proliferation through induction of senescence.
This cytokine can also participate in joint inflammation by attracting neutrophils and T lymphocytes and by triggering the proliferation of memory CD8+ T cells.
Decreasing Orc6 expression by siRNA knock-down triggered cell cycle arrest and decreased cellular proliferation in HCT-116 (wt-p53) cells.
In addition to cell proliferation, S100A14 was able to trigger cell injuries at relatively high dose.
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