Sentence examples for by triggering cell death from inspiring English sources

Therefore, strategies to induce a loss of reduced GSH pool are expected to have a major effect on cell survival and sensitivity toward irradiation by altering the ability of cells to detoxify ROS and therefore by triggering cell death.

On the other hand, the phospholipid remodelling which represented the decrease of unsaturated fatty acid incorporation consecutive to Scd1 depletion played a predominant role in cell survival by triggering cell death [27].

By triggering cell death, it is involved in the clearance of virus-infected cells by the innate and adaptive immune systems.

ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1.

Why some cell types respond to loss of RB by triggering cell death programs whereas others do not is still unknown.

Once DNA damage is detected, activated ATM and its downstream target CHK2 phosphorylate p53 that controls cell fate by either initiating cell cycle arrest to allow for DNA repair or by triggering cell death pathways if the DNA damage is too severe.

Apoptotic initiators, such as caspases-8, -9 and -10, activated procaspases-3 and -7 by specific hydrolysis, thereby triggering cell death by specific apoptotic executioners [ 1, 6, 7].

Photodynamic therapy (PDT) has a direct effect on cancer cells, triggering cell death by autophagy, apoptosis and/or necrosis.

Recently, we have identified a novel nematicidal mechanism by which Cry6Aa triggers cell death through a necrosis-signaling pathway via an interaction with the host protease ASP-1.

Enhanced signaling by antibody-mediated PrPc-aggregation triggers cell death by increasing the generation of reactive oxygen species (ROS) [43], [44].

Gadd 153 (also called CHOP), a transcription factor that is activated by stress to the endoplasmic reticulum, triggers cell death by mechanisms that may include generation of ROS, downregulation of Bcl-2, and upregulation of Bax [ 33].