Sentence examples for by triggering cell cycle from inspiring English sources

The tumor suppressor p53 mediates the cellular response to DNA damage by triggering cell cycle arrest and DNA repair or by evoking cellular senescence and apoptosis [ 1].

These observations suggest that RB loss potentially initiates tumor development by triggering cell cycle re-entry of post-mitotic cells, at least in specific contexts.

GS are of particular interest for human health because they can inhibit carcinogen activation (Hecht 2000; Nakajima et al. 2001) and carcinogenesis by triggering cell cycle arrest and stimulating apoptosis (Wittstock et al. 2003; Hayes et al. 2008).

Production of abnormal amounts of ROS interferes with cellular signaling pathways by free radical targeting of cellular macromolecules including proteins and DNA, as well as by triggering cell cycle arrest and apoptosis.

The question was addressed as to whether the increased sensitivity to, for instance, cisplatin in p53-deficient cells is accompanied by alterations in triggering cell cycle checkpoint activation.

Decreased Orc6 expression in HCT-116 (wt-p53) cells by RNA interference triggered cell cycle arrest at G1 phase.

To check whether the absence of Sei1 could affect the cell cycle, we rendered wt and Sei1-null MEFs quiescent by serum withdrawal, and triggered cell cycle re-entry by serum addition.

Decreasing Orc6 expression by siRNA knock-down triggered cell cycle arrest and decreased cellular proliferation in HCT-116 (wt-p53) cells.

Conversely, inactivation of FoxO proteins by phosphorylation at the conserved Akt sites triggers cell cycle progression by promoting cyclin D1 expression [63].

It has been noted that damaged DNA, blocked replication forks, or nucleoprotein complexes generated by the HR machinery can trigger cell cycle arrest and even cause cell death in certain genetic backgrounds [12 15].

Furthermore, TGFβ2 can trigger cell cycle arrest by induction of p21 expression in other contexts [46].