Sexual reproduction is based on the recognition of opposite mating types through a pheromone/receptor system, triggering cell-cell fusion followed by meiosis.
Two new studies published yesterday in Nature show the animals regrow their hearts by triggering cell division of adult heart muscle cells rather than via stem cells.
On the other hand, the phospholipid remodelling which represented the decrease of unsaturated fatty acid incorporation consecutive to Scd1 depletion played a predominant role in cell survival by triggering cell death [27].
Increased [Ca2+]i triggers phosphatidylserine exposure at the cell surface by triggering cell membrane scrambling [ 9].
A protective effect of short TL on lung cancer risk has a biologically plausible explanation, as short telomeres could protect against cancer by triggering cell senescence or programmed cell death in the presence of functional cell cycle checkpoints and intact apoptotic pathways (44).
These observations suggest that RB loss potentially initiates tumor development by triggering cell cycle re-entry of post-mitotic cells, at least in specific contexts.
Nevertheless, the mechanisms by which PM exposure suppresses EPC levels are not known; it is unclear whether PM depletes EPCs by triggering cell death, stimulating the recruitment of these cells to injured tissue, or preventing their mobilization from the bone marrow.
Cancer peptide vaccines can produce immunologic responses against cancer cells by triggering helper T cell (Th) or cytotoxic T cells (CTL) in association with Major Histocompatibility Complex (MHC) class I or II molecules on the cell surface of antigen presenting cells.
Furthermore, it has been suggested that some cancer chemotherapeutics and chemopreventives exert their effects by triggering either apoptotic cell death or cell cycle transition, and accordingly, the induction of tumor cell apoptosis is used to predict tumor treatment response [ 9, 10].
Specifically, designed peptides can associate with Major Histocompatibility Complex (MHC) class I or II molecules on the cell surface of antigen presenting cells activating anti-tumor effector mechanisms by triggering helper T cell (Th) or cytotoxic T cells (CTL).
In contrast, our findings show that copanlisib suppresses tumor growth in HCC cells mainly by triggering a G1 cell cycle arrest by inhibiting the cyclin D1/CDK4/CDK6 axis (Fig. 8b), without causing apoptosis (Fig. 3).
