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If honokiol was transported by transporter, the binding between membrane transport protein and honokiol would do not achieve saturation at the beginning of time.
Our results demonstrated that honokiol had the preferable abilities of BBB and BCSFB penetrations, and the abilities may contribute to its suitable lipophilicity when honokiol was transported by passive diffusion, or its specific transport mechanisms when honokiol was transported by transporter.
Specifically, for HLA class I, we will also discuss the tools available for the prediction of antigen processing [e.g., proteasomal cleavage and transport by transporter associated with antigen processing (TAP)] — although their impact in the field is limited compared with that of tools for HLA binding prediction.
The rules, based on the 90-percentile values of the drugs' property distributions, apply only to absorption by passive diffusion of compounds through cell membranes; compounds that are actively transported through cell membranes by transporter proteins are exceptions to the rule.
The processed small peptides are then transported into ER lumen by transporter for antigen processing (TAP) complex, loaded onto MHC-I molecule, and subsequently exported via classical secretory pathway to the cell membrane [ 27].
MAGE, BAGE, and GAGE proteins are processed to peptides in cancer cells by low molecular weight polypeptide (LMP) and are then transported to the lumen of the endoplasmic reticulum by transporter associated with antigen processing (TAP).
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Substrates are substances that are transported (by transporters) or catalyzed (by enzymes), while non-substrates are substances that were experimentally tested and found not to be substrates of a particular transporter or enzyme.
The active transport pathway is mediated by transporters and is divided into influx and efflux.
Whatever the case, nonprofessionals are still being used by transporters, which allot 9 or 10 days to travel from New York to Los Angeles.
Contrary to many academic problems which consider distribution only, some vehicle routing problems which must be solved by transporters combine deliveries and pickups.
Potential drug-drug interactions (DDIs) may cause severe, adverse reactions in patients due to alteration in ADME by transporters.
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