The functionality of these cells was not impeded by transgenic expression of CCR4 (Di Stasi et al., 2009).
Our strategy is based on the intrathymic tolerance and disease resistance established by transgenic expression of antigen in the thymus under control of an MHC class II promoter.
The role of PI3K signaling in prostate cancer has been modeled in mice by deletion of PTEN or by transgenic expression of activated AKT, while the role of MYC has been investigated by transgenic expression of MYC.
In this study, we eliminate Shal/Kv4 function in Drosophila neurons by transgenic expression of a dominant-negative DNKv4 subunit.
Neurexin immunoreactivity in NMJs could be restored in nrx[313]/nrx[241] mutants by transgenic expression of a neurexin cDNA (DJ690Gal4/UAS-nrx;nrx[313]/nrx[241]).
We have attempted the fiber type conversion in Pompe muscles by transgenic expression of PGC-1α, a factor which drives the slow muscle metabolic program [18].
In any case, the phenotype of ectopic expression of Tbx1 could be partially rescued by transgenic expression of Smad1 in the same tissues.
Based on evidence obtained by transgenic expression of ETR1 in yeast, Cys4 and Cys6 are important for formation of the disulfide-linked ETR1 homodimer [13].
The heart phenotype caused by ectopic expression of Tbx1 in Ap2aIREScre/+ COET embryos could not be rescued by transgenic expression of Smad1.
Here, we tested this hypothesis by transgenic expression of two chimeric proteins, PrP_Dpl (residues 1 65 of Dpl replaced by residues 1 133 of PrP) and CD_Dpl (residues 90 133 of PrP inserted between residues 65 and 66 of Dpl).
When myostatin is genetically deleted or inhibited by transgenic expression of the myostatin binding protein follistatin, there is a more profound increase in muscle mass and both hypertrophy and hyperplasia of fibers is observed [4], [5].
