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We carried out a multicenter phase II study to evaluate the activity, efficacy and tolerability, of a sequential regimen consisting of three courses of gemcitabine followed by three courses of docetaxel provided there was no evidence of disease progression.
Recently, the results of the SWOG (S0027) phase II trial using a sequential regimen of vinorelbine 25 mg m−2 on days 1 and 8 every 3 weeks for three cycles followed by three courses of docetaxel 35 mg m−2 on days 1, 8, 15 every 4 weeks in patients 70 years of age and older and in patients with PS two of any age were published (Hesketh et al, 2006).
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This study consists of two parts: Study 1 targets the two periods (1994 1998 and 1999 2012) covered by two Courses of Studies (CoS), or sets of legally-binding curriculum guidelines, while Study 2 targets 2013 to the present.
Surgery is followed by six courses of chemotherapy consisting of Paclitaxel and Carboplatin.
The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats.
Those patients underwent thoracotomy with extended lymph node dissection (ND3α) via median sternotomy [ 10], followed by two courses of chemotherapy.
The Topo/NB protocol consisted of two courses of topotecan/cyclophosphamide followed by two courses of ifosfamide/carboplatin/etoposide (ICE) and a later course of cyclophosphamide/doxorubicin/vincristine.
One hundred and thirty-six women were randomly allocated, to one of three treatment regimens: DTX 100 plus FEC 75, alternated for eight courses (ALT); four courses of DTX 100 followed by four courses of FEC 75 (SEQ T); or four courses of FEC 75 followed by four courses of DTX 100 (SEQ F).
The patient was treated with one dose of intrathecal methotrexate, followed by five courses of high dose intravenous methotrexate with leucovorin rescue over the ensuing weeks.
Arm B: Epirubicin (single agent) 120 mg m−2 (bolus i.v). on day 1 every 3 weeks for four courses, followed by four courses of Paclitaxel (single agent) 250 mg m−2 on day 1 every 3 weeks (E → P).
Last, primary chemotherapy using a combination of two courses of CE followed by two courses of CAdO proved to be very efficient as all infants could undergo safe and satisfying surgical excision as shown in our previous NBL 90 study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com