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Nevertheless, it is interesting to note that, some flexibility in placement of one of the probes (the so-called locus-specific oligonucleotide) in the assay design clearly permits many more acceptable assays to be designed than predicted by this strict 50 bp per flank criterion.
The most abundant functional protein categories encoded by this strict core were not unexpectedly those related to translation (80 orthologs), but categories such as coenzyme metabolism (39 orthologs), DNA replication, recombination and repair (35 orthologs), energy production (33 orthologs) and cell membrane biogenesis (29 orthologs) were also highly represented.
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By following this strict control policy, we were able to eliminate MRSA from these five institutions.
By applying this strict binding threshold, we ensured a low level of false positives.
In this strict management by objectives, L County's original plan of "reasonably and lawfully" shutting down coal mines to smoothly reconcile conflicts and industrial restructuring became unrealistic.
However, it's possible to bypass this strict assumption by modelling non-homogeneous (i.e. time-dependent) Markovian stochastic processes.
The absurdity of this is highlighted by the strict rules preventing patients such as Tony Nicklinson and our own case of Martin, people with capacity trying to make decisions to end their own life".
As discussed in Section 3, this is caused by the strict resource reutilization obtained by applying the set of constraints given by Equation (4).
Thus, the ability to detect an increase in crossover rate to 18% or higher argues that we would have detected a 50% crossover rate predicted by the double strand break-repair mechanism [26] had the repair following Ds excision occurred by the strict version of this mechanism.
We addressed this by having strict criteria – practically this was achieved by only including research that, in the authors' opinion, was unequivocally qualitative in nature.
Nor is it driven by the strict exigencies of plot.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com