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The molecular mechanisms responsible for susceptibility to clinical disease caused by this pathogen are poorly understood.
Recent reports on Streptococcus pneumoniae burden worldwide indicate that the health problems caused by this pathogen are far from being solved [1], [2].
The economic burden of S. aureus upon healthcare systems around the world is substantial and new means of controlling diseases caused by this pathogen are clearly needed now [5], [6].
The infections caused by this pathogen are among those least likely to be resolved without effective antibiotic treatment.
Infections caused by this pathogen are usually sporadic, occurring in the summer months and early fall in many countries and usually following the ingestion of improperly handled foods.
Unfortunately, no agents against Acinetobacter spp. are under development and infections caused by this pathogen are emblematic of the mismatch between unmet medical needs and the current antimicrobial research and development pipeline.
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Treatment of infections caused by this pathogen is a significant problem in human medicine [ 1].
Bacteremia caused by this pathogen is mostly related to catheter-related infection and has a good prognosis [ 21].
CAPs caused by this pathogen were associated with a longer LOS and a higher mortality rate as well.
Latent infection by this pathogen is characterized by healed lesions comprising consolidated scar tissue or necrotic lesions that often becomes calcified.
The induction of defence responses and cell death in the susceptible interaction following infection by P. medicaginis suggested this pathogen is not negatively affected by these responses and may promote them.
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