Sentence examples for by this locus from inspiring English sources

Activation of the tumor suppressors encoded by this locus leads to an irreversible cell cycle exit.

In the case of VEGF (Liu et al., J Biol Chem 2001 276 11323), proportional upregulation by the designed transcription factor of all three distinct splice isoforms generated by this locus was observed, illuminating the utility of endogenous gene control in therapeutic settings (proper isoform ratio is essential for the proangiogenic function of VEGF).

However, plant damage increases with increasing numbers of leaf trichomes controlled by this locus.

Additionally, the population-based design of GWAS will produce low OR estimates if disease in only a small portion of the sampled population is mediated by this locus, even if the functional variant were genotyped.

Recently, it has been shown to be a piRNA cluster, and piRNAs homologous to defective copies of ZAM, Idefix, and Gypsy emitted by this locus have been reported [9].

Over half of high-grade human gliomas lack a functional INK4a ARF locus [9], [10] and hence can produce neither p16INK4a nor p19ARF, the two proteins encoded by this locus [11].

Several studies have attempted to identify the precise mechanism by which this locus exerts its pathogenic effect to increase the risk of CAD-related events.

Hence, further functional studies are required to illuminate the mechanism by which this locus influences human longevity.

A proxy SNP, rs4916251 was also associated with increased expression of PIGC in aortic tissue, suggesting that this may the mechanism by which this locus affects vascular remodelling.

Furthermore, when the Pulse Net USA subtyping network recently established a standardized protocol in order to characterize verotoxigenic Escherichia coli O157 by MLVA, this locus was excluded because it showed too much variability during outbreaks, generating data that confounded epidemiological investigations [ 33].

Multiple binding sites are occupied by CREM at this locus in round spermatids, but not by CREB in GC1-spg cells and the locus shows H3K4 trimethylation only in testis (Fig. 4A).