Sentence examples for by this docking from inspiring English sources

The results obtained by this docking procedure are summarized in Fig. 1 and will be discussed subsequently.

The library is then ranked by this docking score.

Since mutation/deletion experiments have clearly demonstrated the importance of the Gab2/Grb2 interaction for the activation of the various effector pathways controlled by this docking protein [ 39, 40], important issues that remain to be resolved for many signalling systems are whether both recruitment sites are equally important, functionally redundant or are used in a stimulus-specific manner.

Given the growing importance of Gab2 in several tumour entities [ 13, 14], we expect that our approach and results will help to shed more light on the various mechanisms by which this docking protein contributes to malignancy.

By default, this dock is open and located on the far right side of the application's window.

It was possible to monitor substrate entering and leaving this docking pose by tracking interactions between residues Glu269 and Asn272 and the C4-OH group on the NPG galactopyranosyl ring.

A recent study by Sampaio et al. (2008) reiterates the importance of the PH domain by showing that it is required for the EGF-triggered recruitment of Gab1 to the plasma membrane in the presence of low doses of EGF, while the recruitment of this docking protein by high doses of EGF relies on Grb2 [ 59].

Complexes generated by the docking methods used in this work always have this property.

5b promoted tubulin polymerization and this was supported by the docking studies, wherein 5b showed significant binding affinity at the colchicine binding pocket of tubulin.

Moreover, even when working on known target-ligand complexes, it is known that, most of the time, the correct pose is not retrieved as the first one ranked by the docking software, and this correct pose is more likely to be found among the ten or the twenty best poses, if ever found.

This hypothesis was further supported by the docking of trans MAB-0 in a homology model.