By this descriptive analysis alone, the first links to indirect consequences on health can be drawn, while the reported problems also support the findings and suggestions of other studies (8, 10, 20).
The weak similarity of CysY to sirohydrochlorin ferrochelatase from B. megaterium (EC 4.99.1.4) [ 27] indicates an involvement in the biosynthesis of the siroheme cofactor of sulphite reductase, but again this assumption cannot be proven conclusively by genetic analysis alone.
Yet although 17 mouse strains have been sequenced3, genome function and regulation cannot be understood by sequence analysis alone.
These results offer a promising path for developing DC subset-specific immunotherapies that cannot be provided by transcriptomic analysis alone.
First, the targets could not be predicted by current in silico approaches or by ChIP analysis alone, but require the intersection of ChIP binding regions and transcriptional profiling to provide a robust set of predictions.
It is intended that this facility will enable biologists inexpert in bioinformatics access to a powerful tool for exploring protein structure relationships beyond what can be achieved by sequence analysis alone.
Some even argued that the existence of political obligations could be established by conceptual analysis alone — a point we return to in §3.
By curating genes whose function has been experimentally determined ('genes of known function') independently of genes predicted by sequence analysis alone (gene models), the rice community has established a flexible yet robust system for bridging these two different approaches to gene structure/function analysis.
By conceptual analysis alone we can know only that wrongness is a property of actions (and perhaps intentions and attitudes); that people are generally opposed to what they regard as wrong; that wrongness is a reason, perhaps a conclusive reason, for opposing an act; and that there are certain acts (e.g. torture for fun) that are wrong.
Deciphering ecosystem functioning, or "what are they doing," by sequence analysis alone is inherently limited.
