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The results of the study aim to contribute to a better understanding of the overlap of GPCRs in chemical space, and to the cross-reactivity observed even among distant biological targets, as defined by their sequence similarities[4].
DNA extracted from AMF spores was processed for cloning and PCR-RFLP of SSU rRNA gene to yield the restriction groups (RGs) followed by their sequence analysis to determine the sequence groups (SGs).
This discrete and one-dimensional representation of tertiary structure, which orders all polypeptide backbone hydrogen bonds by their sequence separation, leads to two main results.
There are five sub-families of DUBs classified by their sequence diversity: the ubiquitin C-terminal hydrolases (UCHs), the ubiquitin-specific peptidases (USPs/UBPs), the ovarian tumor (OTU) domain proteins, the Josephin or Machado-Joseph disease (MJD) proteins, and the JAMM (Jab1/MPN domain-associated metalloisopeptidase) domain proteins.
This relationship can be explained by their sequence patterns.
Similar regions of GraS and BceS were cloned guided by their sequence homology.
Similar(22)
Since, it is believed that the 3D-structure of most proteins is defined by their sequences, utilizing data mining methods to extract hidden knowledge and information from protein sequences, is unavoidable.
The Hu25K probes were matched to known genes by their sequences using BLAST [53], and mapped into official gene symbols.
For this, all SNPs randomly masked in all 5 replicates were binned based by their sequence-derived MAF, and the average correlation in each bin was assessed.
PRT4 target amplicons were identified by their sequences and visualized/analyzed using Genome Assembly Program (GAP) [ 30].
Many insect species show rapid expansion and diversification of detoxification genes, as disclosed by their sequenced genomes.
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